EECP Could Improve Long-Term Renal Function in Cardiac Patients 體外反搏可改善心臟病患者長期的 腎功能

Source From 資料來源 : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847607/

EECP Could Improve Long-Term Renal Function in Cardiac Patients

BACKGROUND:

Enhanced external counterpulsation (EECP) enhances coronary perfusion and reduces left ventricular afterload. However, the role of EECP on renal function in cardiac patients is unknown. Our aim was to assess renal function determined by serum cystatin C in cardiac patients before and after EECP treatment.

METHODS:

A prospective observational longitudinal study was conducted in order to evaluate renal function using serum cystatin C (Cys C) and estimated glomerular filtration rate (GFR) after 35 sessions of EECP treatment in 30 patients with chronic stable angina and/or heart failure. The median (IQR) time for follow-up period after starting EECP treatment was 16 (10-24) months.

RESULTS:

Cys C significantly declined from 1.00 (0.78-1.31) to 0.94 (0.77-1.27) mg/L (p < 0.001) and estimated GFR increased from 70.47 (43.88-89.41) to 76.27 (49.02-91.46) mL/min/1.73 m(2) (p = 0.006) after EECP treatment. Subgroup analysis showed that patients with baseline GFR <60 mL/min/1.73 m(2) or NT-proBNP >125 pg/mL had a significant decrease in Cys C when compared to other groups (p < 0.01).

CONCLUSIONS:

The study demonstrated that EECP could improve long-term renal function in cardiac patients especially in cases with declined renal function or with high NT-proBNP.

TRIAL REGISTRATION:

The study was registered in the clinical trial as International Standard Randomized Controlled Trial Number ISRCTN11560035.

「增強體外反搏治療對心臟病患者 腎功能 的影響」

背景

體外反搏(EECP)可以增加冠狀動脈灌注,減少左心室後負荷。然而,EECP對心臟病患者的 腎功能 的作用尚不清楚。我們的目的是通過血清半胱氨酸蛋白酶C(Cys C)來評估心臟病患者在接受EECP治療前後的 腎功能 。

方法

進行了一項前瞻性觀察性長期研究,以評估30名慢性穩定型心絞痛和/或心臟衰竭患者在接受35次EECP治療後,通過血清半胱氨酸蛋白酶C(Cys C)和估算的腎小球過濾率(GFR)來評估 腎功能 。開始EECP治療後的隨訪中位數(IQR)時間為16個月。

結果

EECP治療後,Cys C從1.00(0.78-1.31)下降到0.94(0.77-1.27)mg/L,估算的GFR從70.47增加到76.27 mL/min/1.73 m²。亞組分析顯示,基線GFR <60 mL/min/1.73 m²或NT-proBNP >125 pg/mL的患者與其他組相比,Cys C顯著下降(p <0.01)。

結論

該研究證明了EECP可以改善心臟病患者的長期 腎功能 ,尤其是對 腎功能 下降或NT-proBNP升高的患者。

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