External counterpulsation has no significant effect in the treatment of non-arteritic anterior ischemic optic neuropathy (NAION) 體外反搏對治療非動脈炎性前部缺血性 視神經病變 (NAION)未有顯著的成效

Source From 資料來源 : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301523/

Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy

BACKGROUND:

To explore the effects of enhanced external counterpulsation (EECP) and its underlying influencing factors in nonarteritic anterior ischemic optic neuropathy (NAION) patients.

METHODS:

Patients at Zhongshan Ophthalmic Center with recent-onset (< 8 weeks) NAION were retrospectively recruited. The patients had decided whether or not they would undergo EECP treatment, and the patients who declined were included in the control group. The effectiveness of EECP was evaluated by comparing the visual function and fellow eye involvement in patients with and without EECP treatment.

RESULTS:

In total, 61 patients (76 eyes) were included. Twenty-nine patients (37 eyes) underwent EECP treatment, while 32 patients (39 eyes) were included in the control group. Mean time from NAION onset to EECP initiation was 27.59 ± 16.70 days. In the EECP group, the mean EECP duration was 31.57 ± 18.45 days. EECP was well tolerated by all patients. However, there was no significant difference in visual function between the EECP and control groups. Furthermore, there was no evidence of the effectiveness of EECP in the subgroup analysis of patients with different systemic health conditions. Among the 42 patients with monocular NAION, the sequential attack rate was comparable between the EECP (27.78%) and control (25.00%) groups.

CONCLUSION:

This study is the first nonrandomized controlled study to evaluate the effectiveness of EECP in NAION patients. Unfortunately, we failed to demonstrate the effectiveness of EECP in NAION at the 6-month follow-up. Any further application of EECP in NAION patients should be cautious.

體外反搏對治療非動脈炎性前部缺血性 視神經病變 (NAION)未有顯著的成效

背景

探討體外反搏治療(EECP)對非動脈炎性前部缺血性 視神經病變 (NAION)患者的效果及其潛在影響因素。

方法

在中山眼科中心招募了近期發生(<8周)NAION的患者,並進行了回顧性研究。患者已決定是否接受EECP治療,而拒絕接受治療的患者會被納入對照組。本研究通過比較接受和不接受EECP治療的患者的視覺功能和其他眼受累情況來評估EECP的有效性。

結果

本研究總共納入了61名患者(76隻眼)。其中29名患者(37隻眼)接受了EECP治療,而32名患者(39隻眼)被納入對照組。NAION發作後到EECP開始治療的平均時間為27.59天。在EECP組中,平均EECP治療持續時間為31.57天。所有患者均能良好耐受EECP治療。然而,EECP組和對照組之間的視覺功能沒有顯著差異。此外,在對具有不同全身健康狀況的患者進行的亞組分析中,沒有證據顯示EECP的有效性。在42名單眼NAION患者中,EECP組(27.78%)和對照組(25.00%)的順序發作率相當。

結論

本研究是第一項非隨機對照研究,評估了EECP在NAION患者中的有效性。遺憾的是,在6個月的隨訪中,我們未能證明EECP在NAION中的有效性。在進一步應用EECP治療NAION患者時應謹慎。

×