External counterpulsation has no significant effect in the treatment of non-arteritic anterior ischemic optic neuropathy (NAION) 體外反搏對治療非動脈炎性前部缺血性 視神經病變 (NAION)未有顯著的成效

Source From 資料來源 : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301523/

Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy


To explore the effects of enhanced external counterpulsation (EECP) and its underlying influencing factors in nonarteritic anterior ischemic optic neuropathy (NAION) patients.


Patients at Zhongshan Ophthalmic Center with recent-onset (< 8 weeks) NAION were retrospectively recruited. The patients had decided whether or not they would undergo EECP treatment, and the patients who declined were included in the control group. The effectiveness of EECP was evaluated by comparing the visual function and fellow eye involvement in patients with and without EECP treatment.


In total, 61 patients (76 eyes) were included. Twenty-nine patients (37 eyes) underwent EECP treatment, while 32 patients (39 eyes) were included in the control group. Mean time from NAION onset to EECP initiation was 27.59 ± 16.70 days. In the EECP group, the mean EECP duration was 31.57 ± 18.45 days. EECP was well tolerated by all patients. However, there was no significant difference in visual function between the EECP and control groups. Furthermore, there was no evidence of the effectiveness of EECP in the subgroup analysis of patients with different systemic health conditions. Among the 42 patients with monocular NAION, the sequential attack rate was comparable between the EECP (27.78%) and control (25.00%) groups.


This study is the first nonrandomized controlled study to evaluate the effectiveness of EECP in NAION patients. Unfortunately, we failed to demonstrate the effectiveness of EECP in NAION at the 6-month follow-up. Any further application of EECP in NAION patients should be cautious.

體外反搏對治療非動脈炎性前部缺血性 視神經病變 (NAION)未有顯著的成效


探討體外反搏治療(EECP)對非動脈炎性前部缺血性 視神經病變 (NAION)患者的效果及其潛在影響因素。