External counterpulsation significantly increases blood flow velocity in the ophthalmic artery in elderly patients with atherosclerosis 體外反搏顯著增加老年動脈粥樣硬化患者 眼動脈 的血流速度

Source From 資料來源 : https://link.springer.com/article/10.1007/s004170100326

Changes in ocular blood flow velocities during external counterpulsation in healthy volunteers and patients with atherosclerosis


External counterpulsation (EECP) is a new noninvasive means of augmenting organ perfusion by applying ECG-triggered diastolic pressure to the vascular bed of the lower limbs. In this study, effects of EECP on changes of ocular blood flow velocities were studied.


Mean, systolic and diastolic flow velocities of the ophthalmic artery were measured by Doppler sonography before and during EECP. Twelve healthy volunteers (age 31.3+/-4.3 years) and 12 patients with severe atherosclerosis (inclusion criteria: two atherosclerotic risk factors, at least one severe coronary stenosis, age 62.1+/-5.3 years) were included in the study.


In healthy subjects, EECP changed diastolic flow velocity of the ophthalmic artery nonsignificantly from 21.6+/-7.7 to 23.7+/-10.5 cm/s. Systolic flow velocity decreased significantly from 36.1+/-13.6 to 28.9+/-10.2 cm/s (P<0.01). Mean flow velocity changed nonsignificantly from 28.1+/-9.4 to 26.5+/-9.9 cm/s. In atherosclerotic patients, mean flow velocity increased significantly from 26.3+/-11.4 to 29.3+/-11.2 cm/s (P<0.001), which was caused by significant diastolic flow augmentation from 19.7+/-9.1 to 23.9+/-9.7 cm/s (P<0.001). Systolic flow velocity was not changed significantly (from 34.2+/-12.8 to 32.6+/-11.8 cm/s).


No significant change of mean blood flow velocity in the ophthalmic artery was found in young healthy subjects. In elderly patients with atherosclerosis, EECP significantly increased blood flow velocity in the ophthalmic artery by 11.4%. This may indicate an ocular perfusion benefit in these patients as a result of EECP and could also explain the increase of perfusion found in patients with retinal ischemia after EECP.

「體外反搏顯著增加老年動脈粥樣硬化患者 眼動脈 的血流速度」




通過多普勒超聲檢測測量 眼動脈 的平均、收縮和舒張期流速,在EECP前後進行對比。研究對象包括12名健康志願者和12名嚴重動脈粥樣硬化患者。


在健康受試者中,EECP對 眼動脈 的舒張期流速無顯著影響,從21.6 cm/s 增加到23.7 cm/s。收縮期流速顯著降低,從36.1 cm/s 降至28.9 cm/s。平均流速無顯著變化,從28.1 cm/s 變為26.5 cm/s。在動脈粥樣硬化患者中,平均流速顯著增加,從26.3 cm/s 增加至29.3 cm/s,這是由於舒張期流速顯著增加,從19.7 cm/s 增至23.9 cm/s。收縮期流速無顯著變化,從34.2 cm/s 變為32.6 cm/s。


在年輕健康受試者中, 眼動脈 的平均血流速度無顯著變化。在老年動脈粥樣硬化患者中,EECP顯著增加 眼動脈 的血流速度,增幅為11.4%。這可能表明EECP對這些患者的眼部灌注產生益處,也可以解釋在EECP後發現視網膜缺血患者的灌注增加。